GAB2 anticorps (C-Term, Internal Region)
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- Antigène Voir toutes GAB2 Anticorps
- GAB2 (GRB2-Associated Binding Protein 2 (GAB2))
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Épitope
- C-Term, Internal Region
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Reactivité
- Humain, Souris, Rat, Chien
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GAB2 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- This antibody reacts to GAB2.
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human. - Purification
- Affinity chromatography
- Immunogène
- Peptide with sequence C-QVDKEKTQALQN, from the internal region (near the C Terminus) of the protein sequence
- Top Product
- Discover our top product GAB2 Anticorps primaire
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- Indications d'application
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Peptide ELISA: 1/64000. Western Blot: 0.5 - 1.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- GAB2 (GRB2-Associated Binding Protein 2 (GAB2))
- Autre désignation
- GAB2 (GAB2 Produits)
- Synonymes
- anticorps GAB2, anticorps AI463667, anticorps D130058I17Rik, anticorps p97, anticorps GRB2 associated binding protein 2, anticorps GRB2-associated binding protein 2, anticorps growth factor receptor bound protein 2-associated protein 2, anticorps GAB2, anticorps gab2, anticorps Gab2
- Sujet
- Gab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs), growth factors and cytokines. Gab2 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors as well as B and T cell antigen receptors, Gab2 acts as a docking protein for several SH2-containing proteins. Upon tyrosine phosphorylation, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, CrkL and SHC.Synonyms: GRB2-associated binder 2, GRB2-associated-binding protein 2, Growth factor receptor bound protein 2-associated protein 2, KIAA0571, pp100
- ID gène
- 9846
- NCBI Accession
- NP_036428
- UniProt
- Q9UQC2
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, BCR Signaling, L'effet Warburg
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