Neuregulin 3 anticorps (C-Term)

N° du produit ABIN374780

Détail du produit anti-Neuregulin 3 anticorps

Antigène: Neuregulin 3 (NRG3)

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Neuregulin 3 est non-conjugé

Application: Western Blotting (WB)

Séquence: C-RNEIQRDSAL TK

Specificité: This antibody recognizes Neuregulin 3.

Réactivité croisée (Details): Species reactivity (expected):Canine.
Species reactivity (tested):Human, Mouse, Rat.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence from the C Terminus of the protein sequence according to NP_001010848.2

Information d'application

Indications d'application: Peptide ELISA: 1/64000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Neuregulin 3

Antigène: Neuregulin 3 (NRG3)

Autre désignation: Neuregulin 3 (NRG3 Produits)

Synonymes: anticorps NRG3, anticorps HRG3, anticorps pro-NRG3, anticorps ska, anticorps RGD1559678, anticorps neuregulin 3, anticorps pro-neuregulin-3, membrane-bound isoform, anticorps NRG3, anticorps nrg3, anticorps LOC100478170, anticorps Nrg3

Sujet: NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization. There are 4 different isoforms.Synonyms: NRG3, Pro-NRG3, Pro-neuregulin-3, membrane-bound isoform

Poids moléculaire: 75.0 kDa (NP_001010848.2).

ID gène: 10718

NCBI Accession: NP_001010848

UniProt: P56975

Pathways: Signalisation RTK