APOC1 anticorps (C-Term)

N° du produit ABIN375143

L’anticorps anti-APOC1 Polyclonal Chèvre est utilisé pour la détection de APOC1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour APOC1 anticorps (C-Term) (ABIN375143)

Antigène: APOC1 (Apolipoprotein C-I (APOC1))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp APOC1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-APOC1 anticorps

Épitope: C-Term

Specificité: This antibody recognizes Apolipoprotein CI (Apo CI).

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence C-ETFQKVKEKLKIDS, from the C-Terminus of the protein sequence according to NP_001636.1.

Information d'application

Indications d'application: Peptide ELISA: Detection Limit Dilution: 1/8000. Immunohistochemistry on Paraffin Sections: 3-5 μg/mL. In paraffin embedded Human Liver shows spotty staining in the cytoplasm of hepatocytes.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur APOC1

Antigène: APOC1 (Apolipoprotein C-I (APOC1))

Autre désignation: Apolipoprotein C I (Apo CI)

Sujet: Apolipoprotein CI is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Apolipoprotein C-I appears to modulate the interaction of APOE with beta migrating VLDL and inhibit binding of beta VLDL to the LDL receptor related protein. At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL).Synonyms: Apo-CI, Ap °C-I, Ap °C1, Apolipoprotein C-I, Apolipoprotein C1

ID gène: 341, 9606

UniProt: P02654

Pathways: Apoptose