SENP1 anticorps (N-Term)

N° du produit ABIN388042

Cet anticorps Lapin Polyclonal détecte spécifiquement SENP1 dans WB et IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour SENP1 anticorps (N-Term) (ABIN388042)

Antigène: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SENP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB0647

Détail du produit anti-SENP1 anticorps

Épitope: AA 28-59, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This SENP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human SENP1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-SENP1 (ABIN388042)

Kim, Choi, Kim, Kim, Lee, Kim, Lee, Choi, Kim, Kim, Chung, Baek: "Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis." dans: Nature cell biology, Vol. 8, Issue 6, pp. 631-9, (2006) (PubMed).

Chen, Chen: "MDM2-ARF complex regulates p53 sumoylation." dans: Oncogene, Vol. 22, Issue 34, pp. 5348-57, (2003) (PubMed).

Détails sur SENP1

Antigène: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Autre désignation: SENP1

Sujet: SENP1 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SENP deconjugates SUMO1 from HIPK2 and from HDAC1, which decreases the transcriptional repression activity of the latter.

Poids moléculaire: 73481

ID gène: 29843

NCBI Accession: NP_001254523, NP_001254524

UniProt: Q9P0U3

Pathways: Positive Regulation of Endopeptidase Activity