SENP1 anticorps (C-Term)

N° du produit ABIN388043

L’anticorps Lapin Polyclonal anti-SENP1 a été validé pour WB. Il convient pour détecter SENP1 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour SENP1 anticorps (C-Term) (ABIN388043)

Antigène: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SENP1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB00649-RB0650

Détail du produit anti-SENP1 anticorps

Épitope: AA 560-590, C-Term

Homologie: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This SENP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 560-590 amino acids from the C-terminal region of human SENP1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-SENP1 (ABIN388043)

Rohira, Chen, Allen, Johnson: "Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression." dans: The Journal of biological chemistry, Vol. 288, Issue 26, pp. 19288-95, (2013) (PubMed).

Meinecke, Cinski, Baier, Peters, Dankbar, Wille, Drynda, Mendoza, Gay, Hay, Ink, Gay, Pap: "Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 12, pp. 5073-8, (2007) (PubMed).

Détails sur SENP1

Antigène: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Autre désignation: SENP1

Sujet: SENP1 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SENP deconjugates SUMO1 from HIPK2 and from HDAC1, which decreases the transcriptional repression activity of the latter.

Poids moléculaire: 73481

ID gène: 29843

NCBI Accession: NP_001254523, NP_001254524

UniProt: Q9P0U3

Pathways: Positive Regulation of Endopeptidase Activity