This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BMPR1A.
BMPR1A
Reactivité: Humain
WB, ELISA, IHC, IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:1000. FC: 1:10~50
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Tominaga, Abe, Ueda, Goto, Nakahara, Murakami, Matsubara, Mima, Nagai, Araoka, Kishi, Fukushima, Jishage, Doi: "Activation of bone morphogenetic protein 4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy." dans: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 20109-16, (2011) (PubMed).
Antigène
BMPR1A
(Bone Morphogenetic Protein Receptor 1A (BMPR1A))
anticorps 10q23del, anticorps ACVRLK3, anticorps ALK3, anticorps CD292, anticorps SKR5, anticorps 1110037I22Rik, anticorps AU045487, anticorps BMPR-IA, anticorps Bmpr, anticorps BMPR-1, anticorps BRK-1, anticorps BMPR1A, anticorps acvrlk3, anticorps alk-3, anticorps alk3, anticorps cd292, anticorps skr5, anticorps BR1a, anticorps alk3tr, anticorps bmpr1a, anticorps zgc:136731, anticorps wu:fe05b06, anticorps wu:fe06e10, anticorps zgc:92227, anticorps bone morphogenetic protein receptor type 1A, anticorps bone morphogenetic protein receptor, type 1A, anticorps bone morphogenetic protein receptor type 1A S homeolog, anticorps bone morphogenetic protein receptor, type IAa, anticorps bone morphogenetic protein receptor, type IAb, anticorps BMPR1A, anticorps Bmpr1a, anticorps bmpr1a, anticorps bmpr1a.S, anticorps bmpr1aa, anticorps bmpr1ab
Sujet
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.