CDKN1B anticorps (pThr187)

N° du produit ABIN389617

Cet anticorps Lapin Polyclonal détecte spécifiquement CDKN1B dans WB et IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour CDKN1B anticorps (pThr187) (ABIN389617)

Antigène: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDKN1B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB07331

Détail du produit anti-CDKN1B anticorps

Épitope: pThr187

Homologie: Ha

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This p27Kip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T187 of human p27Kip1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-CDKN1B (ABIN389617)

van der Sligte, Scherpen, Ter Elst, Guryev, van Leeuwen, de Bont: "Effect of IKZF1 deletions on signal transduction pathways in Philadelphia chromosome negative pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL)." dans: Experimental hematology & oncology, Vol. 4, pp. 23, (2015) (PubMed).

Fang, Zhang, Dizeyi, Chen, Wang, Swanson, Cai, Balk, Yuan: "Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation." dans: The Journal of biological chemistry, Vol. 287, Issue 3, pp. 2090-8, (2012) (PubMed).

Le, Mao, He, Claret, Xia, Ahmed, Hung, Siddik, Bast: "The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells." dans: Journal of the National Cancer Institute, Vol. 103, Issue 18, pp. 1403-22, (2011) (PubMed).

Détails sur CDKN1B

Antigène: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Autre désignation: p27Kip1

Sujet: P27Kip1 is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Poids moléculaire: 22073

ID gène: 1027

NCBI Accession: NP_004055

UniProt: P46527

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy