DDIT4 anticorps (N-Term)

N° du produit ABIN390207

Cet anticorps anti-DDIT4 est un anticorps Lapin Polyclonal détectant DDIT4 dans WB et IHC (p). Adapté pour Humain.

Aperçu rapide pour DDIT4 anticorps (N-Term) (ABIN390207)

Antigène: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDIT4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB12592

Détail du produit anti-DDIT4 anticorps

Épitope: AA 20-49, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DDIT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human DDIT4.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. IHC-P: 1:25. IHC-P: 1:25. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur DDIT4

Antigène: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Autre désignation: DDIT4

Sujet: REDD1 is a novel transcriptional target of p53 induced following DNA damage. During embryogenesis, REDD1 expression mirrors the tissue-specific pattern of the p53 family member p63, and TP63 null embryos show virtually no expression of REDD1, which is restored in mouse embryo fibroblasts following p63 expression. In differentiating primary keratinocytes, TP63 and REDD1 expression are coordinately downregulated, and ectopic expression of either gene inhibits in vitro differentiation. REDD1 appears to function in the regulation of reactive oxygen species (ROS), TP63 null fibroblasts have decreased ROS levels and reduced sensitivity to oxidative stress, which are both increased following ectopic expression of either TP63 or REDD1. Thus, REDD1 encodes a shared transcriptional target that implicates ROS in the p53-dependent DNA damage response and in p63-mediated regulation of epithelial differentiation.

Poids moléculaire: 25371

ID gène: 54541

NCBI Accession: NP_061931

UniProt: Q9NX09

Pathways: Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process