RIPK3 anticorps (C-Term)

N° du produit ABIN392275

Cet anticorps Lapin Polyclonal détecte spécifiquement RIPK3 dans WB et IHC (p). Il présente une réactivité envers Humain et Souris et a été mentionné dans 5+ publications.

Aperçu rapide pour RIPK3 anticorps (C-Term) (ABIN392275)

Antigène: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RIPK3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3319

Détail du produit anti-RIPK3 anticorps

Épitope: AA 489-518, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This RIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-518 amino acids from the C-terminal region of human RIPK3.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-RIPK3 (ABIN392275)

McCullough, McMullen, Das, Roychowdhury, Strainic, Medof, Nagy: "Differential contribution of complement receptor C5aR in myeloid and non-myeloid cells in chronic ethanol-induced liver injury in mice." dans: Molecular immunology, Vol. 75, pp. 122-32, (2017) (PubMed).

Deutsch, Graffeo, Rokosh, Pansari, Ochi, Levie, Van Heerden, Tippens, Greco, Barilla, Tomkötter, Zambirinis, Avanzi, Gulati, Pachter, Torres-Hernandez, Eisenthal, Daley, Miller: "Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury." dans: Cell death & disease, Vol. 6, pp. e1759, (2015) (PubMed).

Dara, Johnson, Suda, Win, Gaarde, Han, Kaplowitz: "Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis." dans: Hepatology (Baltimore, Md.), (2015) (PubMed).

Roychowdhury, Chiang, Mandal, McMullen, Liu, Cohen, Pollard, Feldstein, Nagy: "Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl4 -induced fibrosis but not steatosis or inflammation." dans: Alcoholism, clinical and experimental research, Vol. 36, Issue 7, pp. 1139-47, (2012) (PubMed).

Zorde-Khvalevsky, Abramovitch, Barash, Spivak-Pohis, Rivkin, Rachmilewitz, Galun, Giladi: "Toll-like receptor 3 signaling attenuates liver regeneration." dans: Hepatology (Baltimore, Md.), Vol. 50, Issue 1, pp. 198-206, (2009) (PubMed).

Détails sur RIPK3

Antigène: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Autre désignation: RIPK3

Sujet: RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.

Poids moléculaire: 56887

ID gène: 11035

NCBI Accession: NP_006862

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades