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MYLK3 anticorps (N-Term)

MYLK3 Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal RB3066 unconjugated
N° du produit ABIN392494
  • Antigène Voir toutes MYLK3 Anticorps
    MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))
    Épitope
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 40-69, N-Term
    Reactivité
    • 45
    • 35
    • 18
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 54
    Lapin
    Clonalité
    • 54
    Polyclonal
    Conjugué
    • 20
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MYLK3 est non-conjugé
    Application
    • 50
    • 29
    • 25
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This MYLK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human MYLK3.
    Clone
    RB3066
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Rossi, Todd, Daniels, Bazan, Belayev: "Interferon Stimulated Gene 15 upregulation precedes the development of blood brain barrier disruption and cerebral edema after traumatic brain injury in young mice." dans: Journal of neurotrauma, (2015) (PubMed).

    Rossi, Ralay Ranaivo, Patel, Chrzaszcz, Venkatesan, Wainwright: "Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase." dans: Journal of neuroscience research, Vol. 89, Issue 6, pp. 852-61, (2011) (PubMed).

  • Antigène
    MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))
    Autre désignation
    MYLK3 (MYLK3 Produits)
    Synonymes
    anticorps MLCK, anticorps MLCK2, anticorps caMLCK, anticorps D830007F02Rik, anticorps RGD1305801, anticorps myosin light chain kinase 3, anticorps MYLK3, anticorps Mylk3
    Sujet
    MLCK, a member of the Ser/Thr protein kinase family, is a calcium/calmodulin-dependent enzyme responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments. It is a central determinant in the development of vascular permeability and tissue edema formation. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. MLCK acts as a critical participant in signaling sequences that result in fibroblast apoptosis. Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. The Telokin isoform, which binds calmodulin, has been found in a wide variety of adult and fetal tissues. MLCK is probably down-regulated by phosphorylation. The protein contains 1 fibronectin type III domain and 9 immunoglobulin-like C2-type domains.
    Poids moléculaire
    88393
    ID gène
    91807
    NCBI Accession
    NP_872299
    UniProt
    Q32MK0
    Pathways
    Regulation of Muscle Cell Differentiation
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