PFKFB3 anticorps (C-Term)

N° du produit ABIN392768

Détail du produit anti-PFKFB3 anticorps

Antigène: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Épitope: AA 454-484, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PFKFB3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PFKFB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-484 amino acids from the C-terminal region of human PFKFB3.

Clone: RB04030

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-PFKFB3 (ABIN392768)

Heydasch, Kessler, Warnke, Eschrich, Scholz, Bigl: "Functional diversity of PFKFB3 splice variants in glioblastomas." dans: PloS one, Vol. 16, Issue 7, pp. e0241092, (2021) (PubMed).

Lee, Lee, Yun, Jang, Kang, Kim, Choi, Park: "Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen species." dans: International journal of nanomedicine, Vol. 11, pp. 55-68, (2016) (PubMed).

Reddy, Fernandes, Deshpande, Weisberg, Inguilizian, Abdel-Wahab, Kung, Levine, Griffin, Sattler: "The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity." dans: Leukemia, Vol. 26, Issue 3, pp. 481-9, (2012) (PubMed).

Ando, Uehara, Kogure, Asano, Nakajima, Abe, Kawauchi, Tanaka: "Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3." dans: Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, Vol. 77, Issue 2, pp. 97-105, (2010) (PubMed).

Yamasaki, Hayashi, Okamoto, Osanai, Lee: "Insulin-independent promotion of chemically induced hepatocellular tumor development in genetically diabetic mice." dans: Cancer science, Vol. 101, Issue 1, pp. 65-72, (2010) (PubMed).

Clem, Telang, Clem, Yalcin, Meier, Simmons, Rasku, Arumugam, Dean, Eaton, Lane, Trent, Chesney: "Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth." dans: Molecular cancer therapeutics, Vol. 7, Issue 1, pp. 110-20, (2008) (PubMed).

Telang, Yalcin, Clem, Bucala, Lane, Eaton, Chesney: "Ras transformation requires metabolic control by 6-phosphofructo-2-kinase." dans: Oncogene, Vol. 25, Issue 55, pp. 7225-34, (2006) (PubMed).

Détails sur PFKFB3

Antigène: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Autre désignation: PFKFB3 (PFKFB3 Produits)

Synonymes: anticorps IPFK2, anticorps PFK2, anticorps E330010H22Rik, anticorps iPFK-2, anticorps uPFK-2, anticorps PFKFB3, anticorps zgc:73257, anticorps wu:fc31e01, anticorps 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, anticorps 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 S homeolog, anticorps PFKFB3, anticorps Pfkfb3, anticorps pfkfb3.S, anticorps pfkfb3, anticorps PTRG_09894, anticorps Tsp_06710

Sujet: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

Poids moléculaire: 59609

ID gène: 5209

NCBI Accession: NP_001138915, NP_004557

UniProt: Q16875

Pathways: AMPK Signaling, Regulation of Carbohydrate Metabolic Process