PFKFB3 anticorps (AA 400-500)

N° du produit ABIN6145485

L’anticorps anti-PFKFB3 Polyclonal Lapin est utilisé pour la détection de PFKFB3 dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour PFKFB3 anticorps (AA 400-500) (ABIN6145485)

Antigène: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PFKFB3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PFKFB3 anticorps

Épitope: AA 400-500

Séquence: LDKSAEEMPY LKCPLHTVLK LTPVAYGCRV ESIYLNVESV CTHRERSEDA KKGPNPLMRR NSVTPLASPE PTKKPRINSF EEHVASTSAA LPSCLPPEVP T

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 400-500 of human PFKFB3 (NP_004557.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:1000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PFKFB3

Antigène: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Autre désignation: PFKFB3

Sujet: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.,PFKFB3,IPFK2,PFK2,iPFK-2,Endocrine & Metabolism,Carbohydrate metabolism,AMPK Signaling Pathway,Warburg Effect,PFKFB3

Poids moléculaire: 57 kDa/58 kDa/59 kDa/60 kDa

ID gène: 5209

UniProt: Q16875

Pathways: AMPK Signaling, Regulation of Carbohydrate Metabolic Process