FANCC anticorps (AA 96-112)

N° du produit ABIN401268

Cet anticorps anti-FANCC Polyclonal Lapin (ABIN401268) détecte spécifiquement FANCC dans WB et EIA. L’anticorps est réactif avec des échantillons de Humain et Chimpanzé.

Aperçu rapide pour FANCC anticorps (AA 96-112) (ABIN401268)

Antigène: FANCC (Fanconi Anemia, Complementation Group C (FANCC))

Reactivité: Humain, Chimpanzé

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FANCC est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-FANCC anticorps

Épitope: AA 96-112

Specificité: This antibody is directed against human FANCC protein.

Réactivité croisée (Details): Species reactivity (expected):Chimpanzee (100 %).
Species reactivity (tested):Human.

Purification: Affinity Purified

Immunogène: Synthetic peptide corresponding to amino acids 96-112 of Human FANCC

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1: 20,000 - 1: 80,000. Western blot: 1: 1,000 - 1: 3,000 (Expect a band approximately 63 kDa in size correspondingto FANCC in the appropriate human tissue).

Restrictions: For Research Use only

Stockage

Concentration: 1.45 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Détails sur FANCC

Antigène: FANCC (Fanconi Anemia, Complementation Group C (FANCC))

Autre désignation: FANCC

Sujet: FANCC (also called Protein FACC or Fanconi Anemia Group C protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCC may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCC belongs to the multi-subunit Fanconi Anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. FANCC is mainly found within the nucleus although some protein is localized in the cytoplasm. This protein is ubiquitously expressed. Defects in FANCC are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNAdamaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.Synonyms: FAC, FACC, Fanconi anemia group C protein

ID gène: 2176

NCBI Accession: NP_000127

UniProt: Q00597

Pathways: Réparation de l'ADN