FLT3 anticorps (AA 589-593)

N° du produit ABIN401557

Cet anticorps anti-FLT3 Polyclonal Lapin (ABIN401557) détecte spécifiquement FLT3 dans WB et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour FLT3 anticorps (AA 589-593) (ABIN401557)

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLT3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-FLT3 anticorps

Épitope: AA 589-593

Specificité: This antibody detects endogenous levels of total CD135/FLT3 protein.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography using epitope-specific immunogen.

Immunogène: Peptide sequence around amino acids 589~593 (Y-F-Y-V-D) drerived from Human FLT3.

Information d'application

Indications d'application: Immunofluorescence: 1/100approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at-20 °C.

Détails sur FLT3

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Autre désignation: CD135 / FLT3

Sujet: CD135 is a tyrosine kinase receptor expressed on normal cells including CD34+ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML BC. CD135, also known as FMS-like tyrosine kinase 3, FLT3, STK1, and Flk2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation and has been shown to interact with Grb2, SOCS1, VAV1, and Shc. In humans, expression of Flt3 is restricted to subsets of CD34 positive as well as CD34 negative normal bone marrow cells. In these cells, the level of expression of Flt3 is rather low. Most of the CD34 bright Flt3+ cells co-express CD117 at high levels. They may represent early cycling, but not quiescent stem cells. Flt3+ cells in the CD34lo and CD34- populations do not co-express CD117 Molecule and may represent B lymphoid precursors.Synonyms: FL cytokine receptor, STK1, Stem cell tyrosine kinase 1, Tyrosine-protein kinase receptor FLT3

ID gène: 2322

NCBI Accession: NP_004110

UniProt: P36888

Pathways: Signalisation RTK