DERL1 anticorps (C-Term)

N° du produit ABIN453618

Cet anticorps anti-DERL1 Polyclonal Lapin (ABIN453618) détecte spécifiquement DERL1 dans WB, IHC (p), FACS et EIA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour DERL1 anticorps (C-Term) (ABIN453618)

Antigène: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DERL1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Détail du produit anti-DERL1 anticorps

Épitope: AA 222-251, C-Term

Specificité: This antibody recognizes Human and Mouse Derlin-1 at C-term. Other species not tested.

Purification: Protein A column, followed by peptide affinity purification

Immunogène: KLH conjugated synthetic peptide between 222~251 amino acids from the C-term region of Human Derlin-1 Genename: DERL1

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur DERL1

Antigène: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Autre désignation: Derlin-1

Sujet: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.Synonyms: DER1, DERL1, DERtrin-1, Degradation in endoplasmic reticulum protein 1, Der1-like protein 1

ID gène: 79139

NCBI Accession: NP_001128143

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling