Caspase 1 anticorps (Internal Region)

N° du produit ABIN4901137

Cet anticorps Lapin Polyclonal détecte spécifiquement Caspase 1 dans WB et ELISA. Il présente une réactivité envers Humain et Rat.

Aperçu rapide pour Caspase 1 anticorps (Internal Region) (ABIN4901137)

Antigène: Caspase 1 (CASP1)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Caspase 1 anticorps

Épitope: Internal Region

Fonction: Caspase-1 is a protein encoded by the CASP1 gene which is approximately 45,1 kDa. Caspase-1 is localised to the cytoplasm. It is involved in amyotrophic lateral sclerosis, toll-like receptor signalling pathways, p53 signalling and the TNFR1 pathway. This protein falls under the the cysteine-aspartic acid protease family. upon activation It plays a central role in the execution-phase of cell apoptosis. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules. Caspase-1 is expressed mainly in the spleen and lung. Mutations in the CASP1 gene may result in shigellosis and cowpox. STJ98574 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Caspase-1.

Specificité: Caspase-1 Polyclonal Antibody detects endogenous levels of Caspase-1

Attributs du produit: Rabbit Polyclonal to Caspase-1.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from Caspase-1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000
ELISA 1:10000-20000

Commentaires:

Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur Caspase 1

Antigène: Caspase 1 (CASP1)

Autre désignation: Caspase-1

ID gène: 834

UniProt: P29466

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome