Lamin A/C anticorps

N° du produit ABIN4901871

Cet anticorps anti-Lamin A/C est un anticorps Monoclonal produit chez le Souris, détectant Lamin A/C dans WB, ELISA et IHC (p). Convient pour Humain, Souris et Rat.

Aperçu rapide pour Lamin A/C anticorps (ABIN4901871)

Antigène: Lamin A/C (LMNA)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Lamin A/C est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4E7

Détail du produit anti-Lamin A/C anticorps

Fonction: Mouse monoclonal to Lamin A.

Specificité: Lamin A Monoclonal Antibody detects endogenous levels of Lamin A protein.

Attributs du produit: Mouse Monoclonal to Lamin A.

Purification: Affinity purification

Immunogène: Purified recombinant fragment of human Lamin A expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: WB 1:500-1:2000
IHC 1:200-1:1000
ELISA 1:10000

Commentaires:

In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.

Restrictions: For Research Use only

Stockage

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur Lamin A/C

Antigène: Lamin A/C (LMNA)

Autre désignation: Lamin A

ID gène: 4000

UniProt: P02545

Pathways: Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus