Lamin A/C anticorps

N° du produit ABIN4901872

Cet anticorps Souris Monoclonal détecte spécifiquement Lamin A/C dans WB et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Lamin A/C anticorps (ABIN4901872)

Antigène: Lamin A/C (LMNA)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Lamin A/C est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 3D6-F4-B7

Détail du produit anti-Lamin A/C anticorps

Fonction: Mouse monoclonal to Lamin A.

Specificité: This antibody detects endogenous levels of Lamin A and does not cross-react with related proteins.

Attributs du produit: Mouse Monoclonal to Lamin A.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Purified recombinant human LMNA protein fragments expressed in E.coli.

Isotype: IgG2a

Information d'application

Indications d'application: WB 1:500-2000
ELISA 1:10000-20000

Commentaires:

In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur Lamin A/C

Antigène: Lamin A/C (LMNA)

Autre désignation: Lamin A

Poids moléculaire: 74kDa

ID gène: 4000

UniProt: P02545

Pathways: Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus