PUMA anticorps (AA 76-170)

N° du produit ABIN492517

Détail du produit anti-PUMA anticorps

Antigène: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Épitope: AA 76-170

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PUMA est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: Recognizes Human and Rat PUMA. Other species not tested.

Attributs du produit: Synonyms: BBC3, JFY-1, Bcl-2-binding component 3, p53 up-regulated modulator of apoptosis

Purification: Immunoaffinity Chromotography

Immunogène: A recombinant protein corresponding to amino acids 76–170 of Human PUMA-alpha

Clone: 2A8F6

Isotype: IgG1

Information d'application

Indications d'application: ELISA. Western Blot: PUMA antibody can be used for detection of PUMA at 2.5-5 μg/mL. Positive Control: K562 cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS, 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur PUMA

Antigène: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Autre désignation: PUMA (BBC3 Produits)

Synonymes: anticorps BBC3, anticorps Puma, anticorps JFY-1, anticorps JFY1, anticorps PUMA, anticorps PUMA/JFY1, anticorps BCL2 binding component 3, anticorps Bcl-2 binding component 3, anticorps BBC3, anticorps Bbc3, anticorps bbc3

Sujet: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.Synonyms: BBC3, Bcl-2-binding component 3, JFY-1, p53 up-regulated modulator of apoptosis

ID gène: 27113

UniProt: Q9BXH1

Pathways: Signalisation p53, Positive Regulation of Endopeptidase Activity