XBP1 anticorps (AA 2-160)

N° du produit ABIN492537

Cet anticorps anti-XBP1 est un anticorps Souris Monoclonal détectant XBP1 dans WB, IF et EIA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour XBP1 anticorps (AA 2-160) (ABIN492537)

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp XBP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Clone: 3H1G4

Détail du produit anti-XBP1 anticorps

Épitope: AA 2-160

Specificité: Recognizes XBP1/TREB5 (2-160).

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse and Rat.

Attributs du produit: Synonyms: XBP-1, XBP2, X-box-binding protein 1, Tax-responsive element-binding protein 5

Purification: Immunoaffinity Chromotography.

Immunogène: XBP-1 antibody was raised against recombinant protein corresponding to amino acids 2 to160 of Human XBP-1 (Genbank accession No. BAB82982).

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: XBP1 antibody can be used for detection of XBP1 at 0.5-1 μg/mL. Positive Control: XBP-1 Recombinant Protein. Immunocytochemistry: 2 μg/mL. Positive Control: HepG2 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur XBP1

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Autre désignation: XBP1 / TREB5

Sujet: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) (1). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).Synonyms: Tax-responsive element-binding protein 5, X-box-binding protein 1, XBP-1, XBP2

ID gène: 7494

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response