BRCA1 anticorps (AA 445-620)

N° du produit ABIN4949483

Cet anticorps anti-BRCA1 Monoclonal Souris (Clone BRCA1-1398) (ABIN4949483) détecte spécifiquement BRCA1 dans IF, IHC (p) et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour BRCA1 anticorps (AA 445-620) (ABIN4949483)

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BRCA1 est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: BRCA1-1398

Détail du produit anti-BRCA1 anticorps

Épitope: AA 445-620

Purification: Protein G affinity chromatography

Immunogène: Amino acids 445-620 were used as the immunogen for the BRCA1 antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the BRCA1 antibody should be determined by the researcher.\. Flow Cytometry: 2-4 μg/million cells in 0.1ml,Immunofluorescence: 2-4 μg/mL,IHC (FFPE): 5-10 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the BRCA1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur BRCA1

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Autre désignation: BRCA1

Sujet: BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Pathways: Cycle Cellulaire, Réparation de l'ADN, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus