CD80 anticorps

N° du produit ABIN4949540

Cet anticorps anti-CD80 Monoclonal Souris (Clone C80-1608) (ABIN4949540) détecte spécifiquement CD80 dans ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CD80 anticorps (ABIN4949540)

Antigène: CD80

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD80 est non-conjugé

Application: ELISA

Classe de qualité: Carrier-free

Clone: C80-1608

Détail du produit anti-CD80 anticorps

Fonction: CD80 Antibody / B7-1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Recombinant human protein used as the immunogen for the CD80 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the CD80 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the CD80 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur CD80

Antigène: CD80

Autre désignation: CD80

Sujet: T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31 % overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.

UniProt: P33681

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints