CFTR / Cystic Fibrosis Transmembrane Regulator anticorps

N° du produit ABIN4949561

Cet anticorps anti-CFTR / Cystic Fibrosis Transmembrane Regulator Monoclonal Souris (Clone CFTR-1341) (ABIN4949561) détecte spécifiquement CFTR / Cystic Fibrosis Transmembrane Regulator dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CFTR / Cystic Fibrosis Transmembrane Regulator anticorps (ABIN4949561)

Antigène: CFTR / Cystic Fibrosis Transmembrane Regulator

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CFTR-1341

Détail du produit

Fonction: CFTR Antibody

Purification: Protein G affinity chromatography

Immunogène: Human recombinant protein was used as the immunogen for this CFTR antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CFTR antibody to be titered up or down for optimal performance.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the CFTR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détail du antigène

Antigène: CFTR / Cystic Fibrosis Transmembrane Regulator

Sujet: Cystic fibrosis transmembrane conductance regulator (CFTR) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (MDR1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.