JUP anticorps (N-Term)

N° du produit ABIN4949714

Cet anticorps anti-JUP est un anticorps Souris Monoclonal détectant JUP dans WB, IF et IP. Adapté pour Humain et Souris.

Aperçu rapide pour JUP anticorps (N-Term) (ABIN4949714)

Antigène: JUP (Junction Plakoglobin (JUP))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JUP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 11E4-

Détail du produit anti-JUP anticorps

Épitope: N-Term

Purification: Protein G affinity chromatography

Immunogène: Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Immunofluorescence: 1-2 μg/mL,WB: 0.5-1 μg/mL,Immunoprecipitation: suitable

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Plakoglobin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur JUP

Antigène: JUP (Junction Plakoglobin (JUP))

Autre désignation: Gamma Catenin / Plakoglobin

Sujet: It recognizes a protein of 80-87  kDa, identified as gamma-Catenin or Plakoglobin. The catenins (alpha, beta, gamma and δ,) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location