JUP anticorps (full length, N-Term)

N° du produit ABIN4949714

Cet anticorps anti-JUP Monoclonal Souris (Clone 11E4-) (ABIN4949714) détecte spécifiquement JUP dans WB, IF et FACS. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour JUP anticorps (full length, N-Term) (ABIN4949714)

Antigène: JUP (Junction Plakoglobin (JUP))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JUP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Clone: 11E4-

Détail du produit anti-JUP anticorps

Épitope: full length, N-Term

Fonction: Plakoglobin Antibody / Gamma Catenin (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Plakoglobin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur JUP

Antigène: JUP (Junction Plakoglobin (JUP))

Autre désignation: Plakoglobin

Sujet: It recognizes a protein of 80-87 kDa, identified as gamma-Catenin or Plakoglobin. The catenins (i±, i², i³ and i´) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. i± T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. i± T-catenin binds to i± E-catenin as well as to i²-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for i±-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.

UniProt: P14923

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location