SMAD6 anticorps (AA 358-386)

N° du produit ABIN3032629

Cet anticorps Lapin Polyclonal détecte spécifiquement SMAD6 dans WB, ELISA et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour SMAD6 anticorps (AA 358-386) (ABIN3032629)

Antigène: SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD6 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-SMAD6 anticorps

Épitope: AA 358-386

Réactivité croisée (Details): Expected species reactivity: Mouse

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 358-386 from the human protein was used as the immunogen for this SMAD6 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the SMAD6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at 4°C for up to one month. For long term, aliquot the SMAD6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur SMAD6

Antigène: SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))

Autre désignation: SMAD6

Sujet: SMAD6 acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. [UniProt]

UniProt: O43541

Pathways: Chromatin Binding