ABL1 anticorps (AA 231-260)

N° du produit ABIN3030215

L’anticorps anti-ABL1 Polyclonal Lapin est utilisé pour la détection de ABL1 dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour ABL1 anticorps (AA 231-260) (ABIN3030215)

Antigène: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABL1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-ABL1 anticorps

Épitope: AA 231-260

Fonction: ABL1 Antibody

Réactivité croisée (Details): Expected species reactivity: Mouse

Purification: Antigen affinity

Immunogène: A portion of amino acids 231-260 from the human protein was used as the immunogen for this ABL1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Titration of the ABL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the ABL1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur ABL1

Antigène: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Autre désignation: ABL1

Sujet: The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.

UniProt: P00519

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism