AIM2 anticorps (AA 1-50)

N° du produit ABIN3029828

Détail du produit anti-AIM2 anticorps

Antigène: AIM2 (Absent in Melanoma 2 (AIM2))

Épitope: AA 1-50

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AIM2 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 1-50 from the human protein was used as the immunogen for this AIM2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the AIM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the AIM2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur AIM2

Antigène: AIM2 (Absent in Melanoma 2 (AIM2))

Autre désignation: AIM2 (AIM2 Produits)

Synonymes: anticorps AIM2, anticorps PYHIN4, anticorps Gm1313, anticorps Ifi210, anticorps absent in melanoma 2, anticorps AIM2, anticorps Aim2

Sujet: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. [UniProt]

UniProt: O14862

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome