Aurora A anticorps

N° du produit ABIN3030072

Cet anticorps anti-Aurora A Monoclonal Souris (Clone 1364CT291-108-155) (ABIN3030072) détecte spécifiquement Aurora A dans WB, ELISA et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Aurora A anticorps (ABIN3030072)

Antigène: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Aurora A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 1364CT291-108-155

Détail du produit anti-Aurora A anticorps

Purification: Purified

Immunogène: This AURKA antibody was produced from a mouse immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human AURKA.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Titration of the AURKA antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:25,Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the AURKA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur Aurora A

Antigène: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Autre désignation: AURKA

Sujet: Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

UniProt: O14965

Pathways: Cycle Cellulaire, Asymmetric Protein Localization