Cyclin D1 anticorps (AA 267-294)

N° du produit ABIN3029708

L’anticorps Lapin Polyclonal anti-Cyclin D1 a été validé pour WB et ELISA. Il convient pour détecter Cyclin D1 dans des échantillons de Humain.

Aperçu rapide pour Cyclin D1 anticorps (AA 267-294) (ABIN3029708)

Antigène: Cyclin D1 (CCND1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin D1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Cyclin D1 anticorps

Épitope: AA 267-294

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 267-294 from the human protein was used as the immunogen for this CCND1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the CCND1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CCND1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur Cyclin D1

Antigène: Cyclin D1 (CCND1)

Sujet: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

UniProt: P24385

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling