KIT anticorps (AA 680-711)

N° du produit ABIN3031702

Cet anticorps Lapin Polyclonal détecte spécifiquement KIT dans WB, FACS et ELISA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour KIT anticorps (AA 680-711) (ABIN3031702)

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIT est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Détail du produit anti-KIT anticorps

Épitope: AA 680-711

Réactivité croisée (Details): Expected species reactivity: Pig

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 680-711 from the human protein was used as the immunogen for this CD117 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the CD117 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CD117 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur KIT

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Autre désignation: CD117

Sujet: CD117 is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. It is a receptor tyrosine kinase type III, which binds to stem cell factor (a substance that causes certain types of cells to grow), also known as steel factor or c-kit ligand. When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. Signalling through CD117 plays a role in cell survival, proliferation, and differentiation. [Wiki]

UniProt: P10721

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity