CDK4 anticorps (AA 272-303)
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- Antigène Voir toutes CDK4 Anticorps
- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
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Épitope
- AA 272-303
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CDK4 est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Purification
- Antigen affinity purified
- Immunogène
- A portion of amino acids 272-303 from the rat protein was used as the immunogen for this Cdk4 antibody.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product CDK4 Anticorps primaire
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- Indications d'application
- Titration of the Cdk4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:25,Immunofluorescence: 1:25
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Aliquot the Cdk4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Antigène
- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
- Autre désignation
- Cdk4 (CDK4 Produits)
- Synonymes
- anticorps zgc:153726, anticorps CMM3, anticorps PSK-J3, anticorps Crk3, anticorps 8-6, anticorps CDK4, anticorps CDK4/6, anticorps CG5072, anticorps Cdk4/6, anticorps DmCdk4, anticorps Dmel\\CG5072, anticorps Pk53C, anticorps Pk?7, anticorps cdk, anticorps cdk4, anticorps cdk4/6, anticorps dCdk4, anticorps l(2)05428, anticorps l(2)0671, anticorps l(2)k06503, anticorps l(2)s4639, anticorps l(2)sh0671, anticorps xcdk4, anticorps cyclin-dependent kinase 4, anticorps cyclin dependent kinase 4, anticorps Cyclin-dependent kinase 4, anticorps cyclin-dependent kinase 4 L homeolog, anticorps cdk4, anticorps CDK4, anticorps Cdk4, anticorps cdk4.L
- Sujet
- Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
- UniProt
- P35426
- Pathways
- Cycle Cellulaire, Mitotic G1-G1/S Phases, Regulation of Cell Size
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