DUSP6 anticorps (AA 59-88)

N° du produit ABIN3030776

Détail du produit anti-DUSP6 anticorps

Antigène: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Épitope: AA 59-88

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DUSP6 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): Expected species reactivity: Bovine

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 59-88 from the human protein was used as the immunogen for this DUSP6 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the DUSP6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the DUSP6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur DUSP6

Antigène: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Autre désignation: DUSP6 (DUSP6 Produits)

Synonymes: anticorps HH19, anticorps MKP3, anticorps PYST1, anticorps 1300019I03Rik, anticorps MKP-3, anticorps Mkp3, anticorps wu:fd99d09, anticorps mkp3, anticorps pyst1, anticorps DUSP6, anticorps dusp6, anticorps dual specificity phosphatase 6, anticorps dual specificity phosphatase 6 L homeolog, anticorps Dual specificity protein phosphatase 6, anticorps DUSP6, anticorps Dusp6, anticorps dusp6, anticorps dusp6.L, anticorps dus6

Sujet: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

UniProt: Q16828

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades