EPH Receptor B2 anticorps (AA 1021-1050)

N° du produit ABIN3030826

Cet anticorps Lapin Polyclonal détecte spécifiquement EPH Receptor B2 dans WB, ELISA, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour EPH Receptor B2 anticorps (AA 1021-1050) (ABIN3030826)

Antigène: EPH Receptor B2 (EPHB2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor B2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-EPH Receptor B2 anticorps

Épitope: AA 1021-1050

Purification: Purified

Immunogène: A portion of amino acids 1021-1050 from the human protein was used as the immunogen for this EphB2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the EphB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the EphB2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur EPH Receptor B2

Antigène: EPH Receptor B2 (EPHB2)

Autre désignation: EphB2

Sujet: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ligand-activated form of EphB2, which belongs to the Tyr family of protein kinases, interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. It binds RASGAP through the juxtamembrane tyrosines residues, and also interacts with PRKCABP and GRIP1 This type I membrane protein is expressed in brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. It is preferentially expressed in fetal brain. This protein contains putatively 2 fibronectin type III domains and 1 sterile alpha motif (SAM) domain.

UniProt: P29323

Pathways: Signalisation RTK, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteins