MEF2C anticorps (AA 278-307)

N° du produit ABIN3031904

Détail du produit anti-MEF2C anticorps

Antigène: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Épitope: AA 278-307

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MEF2C est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée (Details): Expected species reactivity: Mouse, Bovine, Pig

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 278-307 from the human protein was used as the immunogen for this MEF2C antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the MEF2C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the MEF2C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur MEF2C

Antigène: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Autre désignation: MEF2C (MEF2C Produits)

Synonymes: anticorps MEF2C, anticorps XMEF2C, anticorps si:ch211-202e12.2, anticorps C5DELq14.3, anticorps DEL5q14.3, anticorps 5430401D19Rik, anticorps 9930028G15Rik, anticorps AV011172, anticorps Mef2, anticorps RGD1563119, anticorps id:ibd5026, anticorps mef2c, anticorps wu:fc05b06, anticorps zgc:64184, anticorps zgc:85726, anticorps myocyte enhancer factor 2C, anticorps MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C), anticorps myocyte enhancer factor 2cb, anticorps MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog, anticorps myocyte enhancer factor 2ca, anticorps MEF2C, anticorps mef2c, anticorps mef2cb, anticorps mef2c.L, anticorps Mef2c, anticorps mef2ca

Sujet: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2. [UniProt]

UniProt: Q06413

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, BCR Signaling