MEF2C anticorps (AA 278-307)

N° du produit ABIN3031904

L’anticorps anti-MEF2C Polyclonal Lapin est utilisé pour la détection de MEF2C dans des échantillons de Humain. Il a été validé pour WB, IHC et ELISA.

Aperçu rapide pour MEF2C anticorps (AA 278-307) (ABIN3031904)

Antigène: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MEF2C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-MEF2C anticorps

Épitope: AA 278-307

Fonction: MEF2C Antibody

Réactivité croisée (Details): Expected species reactivity: Mouse, Bovine, Pig

Purification: Antigen affinity

Immunogène: A portion of amino acids 278-307 from the human protein was used as the immunogen for this MEF2C antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the MEF2C antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot the MEF2C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MEF2C

Antigène: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Autre désignation: MEF2C

Sujet: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2. [UniProt]

UniProt: Q06413

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, BCR Signaling