MIB1 anticorps (AA 13-42)

N° du produit ABIN3031774

Cet anticorps Lapin Polyclonal détecte spécifiquement MIB1 dans ELISA, WB, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour MIB1 anticorps (AA 13-42) (ABIN3031774)

Antigène: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MIB1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-MIB1 anticorps

Épitope: AA 13-42

Réactivité croisée (Details): Expected species reactivity: Mouse, Zebrafish, Xenopus

Purification: Purified

Immunogène: A portion of amino acids 13-42 from the human protein was used as the immunogen for this Mib1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Mib1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:20-1:100,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Mib1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur MIB1

Antigène: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Autre désignation: Mib1 (Mindbomb)

Sujet: MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

UniProt: Q86YT6

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2