ErbB2/Her2 anticorps (pTyr1196)

N° du produit ABIN3029493

Cet anticorps anti-ErbB2/Her2 est un anticorps Lapin Polyclonal détectant ErbB2/Her2 dans WB, ELISA, IF et DB. Adapté pour Humain.

Aperçu rapide pour ErbB2/Her2 anticorps (pTyr1196) (ABIN3029493)

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ErbB2/Her2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Dot Blot (DB)

Détail du produit anti-ErbB2/Her2 anticorps

Épitope: pTyr1196

Purification: Antigen affinity purified

Immunogène: This p-ERBB2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY1196 of human ERBB2.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the p-ERBB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:4000,Immunofluorescence: 1:100,Dot blot: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the p-ERBB2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur ErbB2/Her2

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Autre désignation: Erbb2

Sujet: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

UniProt: P04626

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development