c-FOS anticorps (pThr232)

N° du produit ABIN3030222

Cet anticorps anti-c-FOS est un anticorps Lapin Polyclonal détectant c-FOS dans ELISA et DB. Adapté pour Humain.

Aperçu rapide pour c-FOS anticorps (pThr232) (ABIN3030222)

Antigène: c-FOS (c-Fos) (c-Fos)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp c-FOS est non-conjugé

Application: ELISA, Dot Blot (DB)

Détail du produit anti-c-FOS anticorps

Épitope: pThr232

Purification: Antigen affinity purified

Immunogène: This phospho-c-Fos antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT232 of the human protein.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the phospho-c-Fos antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the phospho-c-Fos antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur c-FOS

Antigène: c-FOS (c-Fos) (c-Fos)

Autre désignation: C-Fos

Sujet: C-Fos is a nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. [UniProt]

UniProt: P01100

Pathways: S100 Proteins