PTEN anticorps (pTyr68)

N° du produit ABIN3032213

Détail du produit anti-PTEN anticorps

Antigène: PTEN (Phosphatase and Tensin Homolog (PTEN))

Épitope: pTyr68

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTEN est non-conjugé

Application: Dot Blot (DB), ELISA

Réactivité croisée (Details): Expected species reactivity: Mouse, Xenopus

Purification: Antigen affinity purified

Immunogène: This phospho-PTEN antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY68 of human PTEN.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the phospho-PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the phospho-PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur PTEN

Antigène: PTEN (Phosphatase and Tensin Homolog (PTEN))

Autre désignation: PTEN (PTEN Produits)

Synonymes: anticorps 10q23del, anticorps BZS, anticorps CWS1, anticorps DEC, anticorps GLM2, anticorps MHAM, anticorps MMAC1, anticorps PTEN1, anticorps TEP1, anticorps 2310035O07Rik, anticorps A130070J02Rik, anticorps AI463227, anticorps B430203M17Rik, anticorps Mmac, anticorps PTENP1, anticorps wu:fc52g04, anticorps zgc:73086, anticorps fa11a08, anticorps fb73f10, anticorps fc83f12, anticorps fd16b10, anticorps fk90e11, anticorps pten, anticorps si:bz1g13.4, anticorps wu:fa11a08, anticorps wu:fb73f10, anticorps wu:fc83f12, anticorps wu:fd16b10, anticorps wu:fk90e11, anticorps phosphatase and tensin homolog, anticorps phosphatase and tensin homolog L homeolog, anticorps phosphatase and tensin homolog A, anticorps phosphatase and tensin homolog B, anticorps PTEN, anticorps Pten, anticorps pten.L, anticorps ptena, anticorps ptenb

Sujet: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

UniProt: P60484

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling