Progesterone Receptor anticorps (AA 349-377)

N° du produit ABIN3032306

L’anticorps anti-Progesterone Receptor Polyclonal Lapin est utilisé pour la détection de Progesterone Receptor dans des échantillons de Humain. Il a été validé pour WB, IHC et ELISA.

Aperçu rapide pour Progesterone Receptor anticorps (AA 349-377) (ABIN3032306)

Antigène: Progesterone Receptor (PGR)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Progesterone Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-Progesterone Receptor anticorps

Épitope: AA 349-377

Fonction: Progesterone Receptor Antibody / Isoforms A & B

Purification: Antigen affinity

Immunogène: A portion of amino acids 349-377 from the human protein was used as the immunogen for this Progesterone Receptor antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Progesterone Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Progesterone Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Progesterone Receptor

Antigène: Progesterone Receptor (PGR)

Autre désignation: Progesterone Receptor

Sujet: As demonstrated in PR-deficient mice, the physiological effects of progesterone depend completely on the presence of its receptor (hPR), a member of the steroid-receptor superfamily of nuclear receptors. The single-copy hPR gene uses separate promoters and translational start sites to produce two isoforms, hPR-A and -B, which are identical except for an additional 165 amino acids present only in the N terminus of -B. Although hPR-B shares many important structural domains as -A, they are in fact two functionally distinct transcription factors, mediating their own response genes and physiological effects with little overlap. Selective ablation of PR-A in a mouse model, resulting in exclusive production of -B, unexpectedly revealed that -B contributes to, rather than inhibits, epithelial cell proliferation both in response to estrogen alone and in the presence of progesterone and estrogen. These results suggest that in the uterus, the PR-A isoform is necessary to oppose estrogen-induced proliferation as well as -B-dependent proliferation. [Wiki]

UniProt: P06401

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration