ROS1 anticorps (C-Term)

N° du produit ABIN3030232

Cet anticorps Lapin Polyclonal détecte spécifiquement ROS1 dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour ROS1 anticorps (C-Term) (ABIN3030232)

Antigène: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ROS1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-ROS1 anticorps

Épitope: C-Term

Purification: Antigen affinity purified

Immunogène: This ROS1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1744-1777 amino acids from the C-terminal region of human ROS1.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the ROS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the ROS1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur ROS1

Antigène: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Autre désignation: ROS1

Sujet: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

UniProt: P08922

Pathways: Signalisation RTK