ROS1 anticorps (C-Term)

N° du produit ABIN6243981

Détail du produit anti-ROS1 anticorps

Antigène: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Épitope: AA 1744-1777, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ROS1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ROS1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1744-1777 amino acids from the C-terminal region of human ROS1.

Clone: RB50575

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur ROS1

Antigène: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Autre désignation: ROS1 (ROS1 Produits)

Synonymes: anticorps MCF3, anticorps ROS, anticorps c-ros-1, anticorps ROS1C, anticorps Ros-1, anticorps c-ros, anticorps ROS proto-oncogene 1, receptor tyrosine kinase, anticorps ROS proto-oncogene 1 , receptor tyrosine kinase, anticorps Ros1 proto-oncogene, anticorps ROS1, anticorps Ros1

Sujet: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

Poids moléculaire: 263915

UniProt: P08922

Pathways: Signalisation RTK