SMAD4 anticorps (AA 400-428)

N° du produit ABIN3032608

Cet anticorps Lapin Polyclonal détecte spécifiquement SMAD4 dans WB, ELISA, IHC, IF et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour SMAD4 anticorps (AA 400-428) (ABIN3032608)

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-SMAD4 anticorps

Épitope: AA 400-428

Réactivité croisée (Details): Expected species reactivity: Mouse, Rat, Bovine, Pig

Purification: Purified

Immunogène: A portion of amino acids 400-428 from the human protein was used as the immunogen for this SMAD4 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the SMAD4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SMAD4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur SMAD4

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Autre désignation: SMAD4

Sujet: In muscle physiology, SMAD4 plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). [UniProt]

UniProt: Q13485

Pathways: Cycle Cellulaire, Chromatin Binding, Autophagy