SOCS4 anticorps (AA 227-254)

N° du produit ABIN3029046

Détail du produit anti-SOCS4 anticorps

Antigène: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Épitope: AA 227-254

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 227-254 from the human protein was used as the immunogen for this SOCS4 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the SOCS4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SOCS4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur SOCS4

Antigène: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Autre désignation: SOCS4 (SOCS4 Produits)

Synonymes: anticorps SOCS7, anticorps socs4, anticorps SOCS4, anticorps 3110032M18Rik, anticorps A730004F22Rik, anticorps AI427843, anticorps AU015727, anticorps AU015859, anticorps Socs7, anticorps SOCS6, anticorps socs7, anticorps socs4a, anticorps suppressor of cytokine signaling 4, anticorps SOCS4, anticorps socs4, anticorps Socs4

Sujet: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. [UniProt]

UniProt: Q8WXH5

Pathways: Signalistation JAK/STAT, EGFR Signaling Pathway