SPHK2 anticorps (AA 590-620)

N° du produit ABIN3032713

Cet anticorps Lapin Polyclonal détecte spécifiquement SPHK2 dans WB, IHC et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour SPHK2 anticorps (AA 590-620) (ABIN3032713)

Antigène: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPHK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-SPHK2 anticorps

Épitope: AA 590-620

Purification: Purified

Immunogène: A portion of amino acids 590-620 from the human protein was used as the immunogen for this SPHK2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the SPHK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SPHK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur SPHK2

Antigène: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Autre désignation: SPHK2

Sujet: Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.

UniProt: Q9NRA0

Pathways: VEGF Signaling