STIM1 anticorps (AA 509-538)

N° du produit ABIN3032757

Détail du produit anti-STIM1 anticorps

Antigène: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Épitope: AA 509-538

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STIM1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée (Details): Expected species reactivity: Mouse

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 509-538 from the human protein was used as the immunogen for this STIM1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the STIM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the STIM1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur STIM1

Antigène: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Autre désignation: STIM1 (STIM1 Produits)

Synonymes: anticorps stim1, anticorps MGC76045, anticorps STIM1, anticorps si:dkey-24p1.5, anticorps MGC154748, anticorps si:ch211-112l17.2, anticorps Stim1, anticorps D11S4896E, anticorps GOK, anticorps TAM, anticorps SIM, anticorps stromal interaction molecule 1, anticorps stromal interaction molecule 1a, anticorps stromal interaction molecule 1 L homeolog, anticorps stromal interaction molecule 1b, anticorps STIM1, anticorps stim1, anticorps stim1a, anticorps stim1.L, anticorps stim1b, anticorps Stim1

Sujet: This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.

UniProt: Q13586

Pathways: TCR Signaling, BCR Signaling