SUMO1 anticorps (AA 55-86)

N° du produit ABIN3032769

Cet anticorps anti-SUMO1 Polyclonal Lapin (ABIN3032769) détecte spécifiquement SUMO1 dans WB, IHC, ELISA et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SUMO1 anticorps (AA 55-86) (ABIN3032769)

Antigène: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUMO1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Détail du produit anti-SUMO1 anticorps

Épitope: AA 55-86

Fonction: SUMO Antibody

Réactivité croisée (Details): Expected species reactivity: Mouse, Rat, Bovine, Pig

Purification: Purified

Immunogène: A portion of amino acids 55-86 from human SUMO1 was used as the immunogen for this SUMO antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the SUMO antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SUMO antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur SUMO1

Antigène: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Autre désignation: SUMO1

Sujet: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1, this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. [UniProt]

UniProt: P63165

Pathways: M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway