Tuberin anticorps (AA 1364-1393)

N° du produit ABIN3029314

Cet anticorps Lapin Polyclonal détecte spécifiquement Tuberin dans ELISA et WB. Il présente une réactivité envers Humain.

Aperçu rapide pour Tuberin anticorps (AA 1364-1393) (ABIN3029314)

Antigène: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tuberin est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-Tuberin anticorps

Épitope: AA 1364-1393

Réactivité croisée (Details): Expected species reactivity: Mouse, Rat

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 1364-1393 from the human protein was used as the immunogen for this TSC2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the TSC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the TSC2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur Tuberin

Antigène: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Autre désignation: TSC2

Sujet: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

UniProt: P49815

Pathways: Signalisation RTK, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus