Lamin A/C anticorps (AA 59-249)

N° du produit ABIN497933

L’anticorps Lapin Polyclonal anti-Lamin A/C a été validé pour WB et IHC (p). Il convient pour détecter Lamin A/C dans des échantillons de Humain, Souris, Rat et Boeuf (Vache).

Aperçu rapide pour Lamin A/C anticorps (AA 59-249) (ABIN497933)

Antigène: Lamin A/C (LMNA)

Reactivité: Humain, Souris, Rat, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin A/C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Lamin A/C anticorps

Épitope: AA 59-249

Specificité: Recognizes Lamin A/C.

Réactivité croisée (Details): Species reactivity (expected):Mouse (98 %), Rat (98 %), Bovine (98 %).
Species reactivity (tested):Human.

Purification: Antigen-Affinity Chromatography.

Immunogène: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 59 and 249 of Lamin A/C

Information d'application

Indications d'application: Western blotting: 1/500-1/3000. Positive Controls: HeLa, HeLa NucleusImmunohistochemistry on Paraffin Sections: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.1 M Tris, 0.1 M Glycine, 10 % Glycerol and 0.01 % Thimerosal as preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C.

Détails sur Lamin A/C

Antigène: Lamin A/C (LMNA)

Autre désignation: Lamin-A/C (LMNA)

Sujet: Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. Lamin A, Lamin C and lamin Adel 10, while the B type lamins include two proteins arising from two distinct genes, i.e. Lamin B1 and Lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A type lamins coincides with cell differentiation and as A type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A type lamins.Synonyms: 70 kDa Lamin, LMN1, LMNA, Lamin A, Lamin A + C, Lamin-A/C, NY-REN-32, NYREN32, Nuclear Envelope Marker, Renal carcinoma antigen NY-REN-32

ID gène: 4000, 9606

UniProt: P02545

Pathways: Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus