Beclin 1 anticorps (C-Term)

N° du produit ABIN497977

Cet anticorps Lapin Polyclonal détecte spécifiquement Beclin 1 dans WB, IF et EIA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour Beclin 1 anticorps (C-Term) (ABIN497977)

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Beclin 1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-Beclin 1 anticorps

Épitope: C-Term

Specificité: Recognizes Beclin-1 (C-term).

Purification: Immunoaffinity Chromatography

Immunogène: Beclin-1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of Human Beclin-1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: Beclin-1 antibody can be used for the detection of Beclin-1 at 0.5-1 μg/mL. Positive Control: A431 Cell Lysate. Immunocytochemistry. Positive Control: A431 Cell Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Beclin 1

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Autre désignation: Beclin-1

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2). Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6 (3,4), is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors (5). Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death (6).Synonyms: BECN1, Coiled-coil myosin-like BCL2-interacting protein, GT197, Protein GT197

ID gène: 8678

NCBI Accession: NP_003757

UniProt: Q14457

Pathways: Autophagy